Geographical variations in the prevalence of atopic sensitization in six study sites across Canada
- 14 June 2010
- Vol. 65 (11), 1404-1413
- https://doi.org/10.1111/j.1398-9995.2010.02399.x
Abstract
Geographical variations in atopic sensitization in Canada have not been described previously. This study used the standardized protocol of the European Community Respiratory Health Survey-1 (ECRHS-1) to investigate the distribution and predictors of atopic sensitization in six sites across Canada and to compare the results with some ECRHS-1 centers. Adults aged 20-44 years in six study sites across Canada underwent allergy skin testing using 14 allergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae) cat, cockroach, grasses (Timothy grass, Kentucky grass), molds (Cladosporium herbarium, Alternaria alternata, Aspergillus fumigatus, Penicillium), trees (tree mix, birch, Olea europea), and common ragweed. The overall prevalence of atopy (skin test over 0 mm to any allergen) was 62.7%. There was significant geographical variation in the prevalence of atopy in the six study sites (lowest 55.6% [95% C.I.51.3-59.9] in Prince Edward Island, highest 66.0 [61.7-70.3] in Montreal) and of sensitization to each of the allergens tested even after adjustment for confounders. When the first eight of the nine allergens in the ECRHS were used to estimate the prevalence of atopic sensitization, the prevalence of atopy in Canada was 57% compared with 35.2% overall for centers in the ECRHS. The prevalence of atopy in Vancouver (57% [52.3-61.8]) was close to that of Portland, Oregon (52.1% [46.2-58.0]). There was a significant variation in atopic sensitization among different study sites across Canada. The prevalence of atopic sensitization is relatively high in Canada compared with sites in the ECRHS and this may, in part, account for the high prevalence of asthma and asthma symptoms in Canada.Keywords
This publication has 24 references indexed in Scilit:
- Cigarette smoking and allergic sensitization: A 32-year population-based cohort studyJournal of Allergy and Clinical Immunology, 2008
- Influence of early day-care exposure on total IgE levels through age 3 yearsJournal of Allergy and Clinical Immunology, 2007
- Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey IClinical & Experimental Allergy, 2007
- Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey IAllergy, 2007
- Early childhood environment related to microbial exposure and the occurrence of atopic disease at school ageAllergy, 2005
- Presence and timing of cat ownership by age 18 and the effect on atopy and asthma at age 28Journal of Allergy and Clinical Immunology, 2004
- Effects of cigarette smoke on the immune systemNature Reviews Immunology, 2002
- Exposure to farming in early life and development of asthma and allergy: a cross-sectional surveyThe Lancet, 2001
- The association of smoking with sensitization to common environmental allergens: Results from the European Community Respiratory Health SurveyJournal of Allergy and Clinical Immunology, 1999
- Immediate Skin Reactivity and Its Relationship to Age, Sex, Smoking, and Occupational ExposureArchives of environmental health, 1985