Multifunctional redox catalysts as selective enhancers of oxidative stress
- 9 June 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 3 (14), 2579-2587
- https://doi.org/10.1039/b502197a
Abstract
Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.Keywords
This publication has 33 references indexed in Scilit:
- Asymmetric organotellurides as potent antioxidants and building blocks of protein conjugatesOrganic & Biomolecular Chemistry, 2005
- Oxidative stress attenuates Fas-mediated apoptosis in Jurkat T cell line through Bfl-1 inductionOncogene, 2004
- Interaction of selenium compounds with zinc finger proteins involved in DNA repairJBIC Journal of Biological Inorganic Chemistry, 2004
- Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potentialOrganic & Biomolecular Chemistry, 2003
- Ebselen, a Selenium-Containing Redox Drug, Releases Zinc from MetallothioneinBiochemical and Biophysical Research Communications, 1998
- New selenenylation method. Synthesis of setenonaphthoquinones and selenoquinolinequinones mediated by phenyl selenide ionJournal of the Chemical Society, Perkin Transactions 1, 1991
- New Colorimetric Cytotoxicity Assay for Anticancer-Drug ScreeningJNCI Journal of the National Cancer Institute, 1990
- Redox Buffering Ability of Lymphoid Cells Evaluated by the Oxidation of 2′,7′-DichlorofluorescinFree Radical Research Communications, 1990
- Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIAJCI Insight, 1973
- Structure of Gossypol. XXIV. Attempts to Prepare Desapogossypolone Tetramethyl Ether1Journal of the American Chemical Society, 1941