Clinical features and treatment outcomes of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma: a single center retrospective analysis of 64 patients in China
Open Access
- 18 November 2019
- journal article
- research article
- Published by Press of International Journal of Ophthalmology (IJO Press) in International Journal of Ophthalmology
- Vol. 12 (11), 1731-1736
- https://doi.org/10.18240/ijo.2019.11.11
Abstract
AIM: To investigate the clinical features, treatment and prognosis of primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML). METHODS: A retrospective analysis was performed on 64 patients with POAML who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2006 to December 2018. RESULTS: With a median follow-up of 61mo (range, 2-156mo), estimated overall survival (OS) rate and progression-free survival (PFS) rate at 10y reached 94.5% and 61.5%, respectively. Median OS time and PFS time were not reached. During this period, only 3 patients died, but none of them died directly due to disease progression. One patient (1.6%) developed transformation to diffuse large B-cell lymphoma (DLBCL). Of the 56 patients achieved complete remission after first-line treatment, 5 (8.9%) developed local and/or systemic relapse eventually. Patients >= 60y had significantly shorter PFS than younger patients (P=0.01). For patients with early stages (Ann Arbor stage I and stage II), univariate analysis confirmed that radiotherapy dose lower than 32 Gy were independently associated with shorter PFS (P=0.04). Other factors including gender, bone marrow involvement, the initial location of the disease, and the laterality were not associated with PFS. CONCLUSION: The data from our center indicate that POAML has a slow clinical progression and has an excellent clinical outcome. Patients with POAML harbor a continual risk of relaps and transformation to aggressive subtype of lymphoma.Keywords
This publication has 24 references indexed in Scilit:
- Primary ocular adnexal mucosa‐associated lymphoid tissue lymphoma (MALT): single institution experience in a large cohort of patientsBritish Journal of Haematology, 2010
- Extranodal marginal zone lymphoma of the ocular adnexaBlood, 2009
- Primary Ocular Adnexal MALT Lymphoma: A Long-term Follow-up Study of 114 PatientsJapanese Journal of Clinical Oncology, 2007
- Ocular adnexal lymphoma: a review of clinicopathologic features and treatment optionsBlood, 2006
- Rapidly Increasing Incidence of Ocular Non-Hodgkin LymphomaJNCI Journal of the National Cancer Institute, 2006
- The Clinical Characteristics and Treatment Results of Ocular Adnexal LymphomaKorean Journal of Ophthalmology, 2006
- Ocular adnexal marginal zone B cell lymphoma: a clinical and pathologic study of 23 casesVirchows Archiv, 2005
- Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control StudyAmerican Journal of Epidemiology, 2005
- Thyroid orbitopathy possibly predisposes to late-onset of periocular lymphomaEye, 2005
- Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical OutcomeJournal of Clinical Oncology, 2003