The Effects of Intranasal Budesonide on Allergen-induced Production of Interleukin-5 and Eotaxin, Airways, Blood, and Bone Marrow Eosinophilia, and Eosinophil Progenitor Expansion in Sensitized Mice
- 15 July 2002
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 166 (2), 146-153
- https://doi.org/10.1164/rccm.2008161
Abstract
We have previously demonstrated that allergen inhalation induces expansion of bone marrow eosinophil progenitors in sensitized mice and subjects with asthma and that the inhaled corticosteroid, budesonide, reduced baseline but not allergen-induced increase in bone marrow eosinophil/basophil progenitors (EoB-CFU) in subjects with asthma. Here, we evaluated the effects of intranasal budesonide on allergen-induced increases in interleukin (IL)-5 and eotaxin in the airway and peripheral blood, expansion of bone marrow Eo-CFU and eosinophilia in bone marrow, peripheral blood and airway, as well as airway hyperresponsiveness, in ovalbumin (OVA)-sensitized mice. Budesonide treatment attenuated allergen-induced eosinophilia in bone marrow, peripheral blood, and airways as well as allergen-induced increases in bone marrow eosinophil progenitors but not allergen-induced increases in IL-5 or eotaxin 12 h following the second of two daily exposures to allergen; at later time points treatment was associated with attenuation of IL-5, eosinophilia, Eo-CFU, and airway hyperresponsiveness. These results suggest that a component of the mechanism by which corticosteroid treatment attenuates allergen-induced airway inflammation is through suppression of bone marrow eosinophilopoiesis, and that this is likely not mediated simply through the blocking of IL-5 production at the airway.This publication has 46 references indexed in Scilit:
- Regulation of IL–5 and IL–5 Receptor Expression in the Bone Marrow of Allergic AsthmaticsInternational Archives of Allergy and Immunology, 1999
- Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.JCI Insight, 1998
- Effect of Inhaled Formoterol and Budesonide on Exacerbations of AsthmaThe New England Journal of Medicine, 1997
- Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of AsthmaThe Journal of Experimental Medicine, 1997
- Allergen-induced airway reactions in atopic asthmatics correlate with allergen-specific IL-5 response by BAL cellsRespirology, 1997
- Identification of a Mouse Eosinophil Receptor for the CC Chemokine EotaxinBiochemical and Biophysical Research Communications, 1996
- Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severityJournal of Allergy and Clinical Immunology, 1991
- Stimulation of Human Eosinophilopoiesis by Hydrocortisone in vitroActa Haematologica, 1987
- Effects of glucocorticoids on eosinophil colony growthJournal of Allergy and Clinical Immunology, 1986
- EFFECTS OF A GLUCOCORTICOID (DEXAMETHASONE) ON THE EOSINOPHILS OF THE RATJournal of Endocrinology, 1967