Acalculous Cholecystitis in a Patient with Hepatocellular Carcinoma on Sorafenib
Open Access
- 23 November 2011
- journal article
- Published by Hindawi Limited in ISRN Gastroenterology
- Vol. 2011, 1-4
- https://doi.org/10.5402/2011/201529
Abstract
A 67-year-old woman with compensated cirrhosis type B associated with hepatocellular carcinoma was started on sorafenib for multiple pulmonary metastases. The patient developed right upper quadrant pain and high fever 4 weeks later. Imaging revealed marked enlargement of the gallbladder without calculi. Following percutaneous transhepatic gallbladder aspiration, her symptoms resolved, but the gallbladder remained enlarged. Laparoscopic cholecystectomy was performed. Arteriolar occlusion with intimal thickening in the muscular layer of the gallbladder was seen sporadically. The fact that this patient had no risk factors for acalculous cholecystitis suggested that the cholecystitis resulted from ischemia, implying a strong causal relationship with sorafenib.Keywords
This publication has 15 references indexed in Scilit:
- Acalculous Cholecystitis in a Patient with Metastatic Renal Cell Carcinoma Treated with SunitinibClinical Genitourinary Cancer, 2009
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialThe Lancet Oncology, 2008
- Sorafenib in Advanced Hepatocellular CarcinomaThe New England Journal of Medicine, 2008
- Emphysematous Cholecystitis in a Patient with Gastrointestinal Stromal Tumor Treated with SunitinibPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007
- Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft modelsCancer Chemotherapy and Pharmacology, 2006
- Hypoxia-Induced Pulmonary Vascular RemodelingCirculation Research, 2006
- BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and AngiogenesisCancer Research, 2004
- Acute acalculous cholecystitis: incidence, risk factors, diagnosis, and outcome.1998
- Acute cholecystitis in diabetic patients.1995
- Cholecystitis Without GallstonesHPB Surgery, 1990