Adipose tissue in control of metabolism
Top Cited Papers
- 1 December 2016
- journal article
- review article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 231 (3), R77-R99
- https://doi.org/10.1530/joe-16-0211
Abstract
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity. Therefore, adipose tissue dysfunction plays a prominent role in the development of obesity and its related disorders such as insulin resistance, cardiovascular disease, diabetes, depression and cancer. In this review, we will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.Keywords
This publication has 178 references indexed in Scilit:
- Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced ObesityCell Metabolism, 2011
- Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and diseaseCell and tissue research, 2010
- Inducible lineage tracing of Pax7‐descendant cells reveals embryonic origin of adult satellite cellsgenesis, 2010
- Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown FatCell Metabolism, 2010
- TGR5-Mediated Bile Acid Sensing Controls Glucose HomeostasisCell Metabolism, 2009
- Histone Methylation Regulator PTIP Is Required for PPARγ and C/EBPα Expression and AdipogenesisCell Metabolism, 2009
- Beneficial Effects of Subcutaneous Fat Transplantation on MetabolismCell Metabolism, 2008
- Transcriptional Control of Brown Fat Determination by PRDM16Cell Metabolism, 2007
- Transcriptional control of adipocyte formationCell Metabolism, 2006
- Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factorCell, 1994