Oncogene amplification in solid tumors
- 31 August 1999
- journal article
- review article
- Published by Elsevier BV in Seminars in Cancer Biology
- Vol. 9 (4), 319-325
- https://doi.org/10.1006/scbi.1999.0126
Abstract
The term gene amplification refers to the selective increase of the gene copy number and is better designated as DNA amplification. It should not be confused with elevated gene expression, although amplification generally does result in enhanced levels of the products encoded by the amplified gene. Amplification is one of the mechanisms by which cells can meet the demand for synthesis of specific gene products in amounts exceeding the transcriptional capacity of a single copy gene. Cytogenetic studies of human and animal tumor cells have provided evidence for mysterious chromosomal abnormalities including double minutes (DMs), C-bandless chromosomes (CMs) or homogeneously staining chromosomal regions (HSRs) diagnostic for amplified DNA. MYCN has been the first oncogene found amplified in direct preparations of solid tumors, the group of oncogenes undergoing amplification has considerably expanded since. Today amplification of oncogenes is recognized as a major player in the development of many solid tumors in humans and at the same time is a reflection of the genetic instability of solid tumor cells.Keywords
This publication has 36 references indexed in Scilit:
- Amplification of oncogenes in human cancer cellsBioEssays, 1998
- N-MYC Oncogene Amplification: A Consequence of Genomic Instability in Human NeuroblastomaThe Neuroscientist, 1995
- Amplification of cellular oncogenes: A predictor of clinical outcome in human cancerGenes, Chromosomes and Cancer, 1990
- Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA.Molecular and Cellular Biology, 1989
- Recent progress in understanding mechanisms of mammalian DNA amplificationCell, 1989
- Oncogene Amplification in Tumor CellsAdvances in Cancer Research, 1986
- Gene amplification in cultured animal cellsCell, 1984
- GENE AMPLIFICATIONAnnual Review of Biochemistry, 1984
- Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumourNature, 1983
- Amplification of genes for chorion proteins during oogenesis in Drosophila melanogasterProceedings of the National Academy of Sciences of the United States of America, 1980