Epidemiology of hepatocellular carcinoma in Japan
Open Access
- 16 January 2009
- journal article
- Published by Springer Science and Business Media LLC in The Esophagus
- Vol. 44 (S19), 102-107
- https://doi.org/10.1007/s00535-008-2251-0
Abstract
Primary liver cancer, 95% of which is hepatocellular carcinoma (HCC), is ranked third in men and fifth in women as a cause of death from malignant neoplasms in Japan. The number of deaths and death rate of HCC began to increase sharply in 1975. These numbers peaked at 34 510 and 27.4/100 000, respectively, in 2004, but decreased to 33 662 annual deaths and a 26.7/100 000 death rate in 2006. Although hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are both major causes of HCC, HCV-related HCC represents 70% of all cases. The incidence of HCC without hepatitis B surface antigen (HBsAg) or antibodies to HCV (anti-HCV) accounts for 8%–15% of HCC patients nationwide. Geographically, HCC is more frequent in western than eastern Japan, and death rates of HCC in each prefecture correlate with anti-HCV, but not HBsAg, prevalence. Interferon therapy for chronic hepatitis C reduces the risk of development of HCC, especially among patients with sustained virological response. Further research should focus on the mechanisms of carcinogenesis by HCV and HBV, development of more effective treatments, and establishment of early detection and preventative approaches. Better understanding of HCC unrelated to HCV and HBV, possibly caused by steatohepatitis and diabetes, should also be a major concern in future studies.Keywords
This publication has 16 references indexed in Scilit:
- Report of the 17th Nationwide Follow‐up Survey of Primary Liver Cancer in Japan†Hepatology Research, 2007
- Differences of Hepatocellular Carcinoma Patients with Hepatitis B Virus Genotypes of Ba, Bj or C in JapanIntervirology, 2005
- Benefit of interferon therapy in hepatocellular carcinoma prevention for individual patients with chronic hepatitis CGut, 2004
- Influence of hepatitis B virus genotypes on the progression of chronic type B liver diseaseHepatology, 2003
- Survey and follow-up study of primary liver cancer in Japan. Report 14.Kanzo, 2000
- Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1,643 patients using statistical bias correction with proportional hazard analysisHepatology, 1999
- Survey and follow-up study of primary liver cancer in Japan-Report 13.Kanzo, 1999
- Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis CHepatology, 1998
- Survey and follow-up study of primary liver cancer in Japan-Report 12.Kanzo, 1997
- Survey and follow-up study of primary liver cancer in Japan. Report 11.Kanzo, 1995