Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma: Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images
Open Access
- 2 September 2010
- journal article
- research article
- Published by Hindawi Limited in Journal of Oncology
- Vol. 2010, 1-6
- https://doi.org/10.1155/2010/821048
Abstract
Purpose. To investigate the correlation of Apperent Diffusion Coefficient (ADC) values in invasive ductal breast carcinomas with detailed histologic features and enhancement ratios on dynamic contrast-enhanced MRI.Methods and Materials. Dynamic MR images and diffusion-weighted images (DWIs) of invasive ductal breast carcinomas were reviewed in 25 (26 lesions) women. In each patient, DWI, T2WI, T1WI, and dynamic images were obtained. The ADC values of the 26 carcinomas were calculated with b-factors of 0 and 1000 s/ using echoplanar DWI. Correlations of the ADC values were examined on dynamic MRI with enhancement ratios (early to delayed phase: E/D ratio) and detailed histologic findings for each lesion, including cellular density, the size of cancer nests, and architectural features of the stroma (broad, narrow, and delicate) between cancer nests.Results. The mean ADC was /sec. Cellular density was significantly correlated with ADC values () and E/D ratios (). The ADC values were also significantly correlated to features of the stroma (broad to narrow, ).Conclusion. The findings suggest that DWIs reflect the growth patterns of carcinomas, including cellular density and architectural features of the stroma, and E/D ratios may also be closely correlated to cellular density.Keywords
This publication has 17 references indexed in Scilit:
- Quantitative diffusion weighted imaging for differentiation of benign and malignant breast lesions: The influence of the choice of b‐valuesJournal of Magnetic Resonance Imaging, 2010
- Quantitative diffusion imaging in breast cancer: A clinical prospective studyJournal of Magnetic Resonance Imaging, 2006
- ADC Mapping of Benign and Malignant Breast TumorsMagnetic Resonance in Medical Sciences, 2005
- Quantitative evaluation of diffusion-weighted magnetic resonance imaging of focal hepatic lesionsWorld Journal of Gastroenterology, 2005
- Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervixEuropean Radiology, 2004
- Diffusion-weighted Imaging of Breast Cancer with the Sensitivity Encoding Technique: Analysis of the Apparent Diffusion Coefficient ValueMagnetic Resonance in Medical Sciences, 2004
- Differentiation of clinically benign and malignant breast lesions using diffusion‐weighted imagingJournal of Magnetic Resonance Imaging, 2002
- Breast Masses with Peripheral Rim Enhancement on Dynamic Contrast-enhanced MR Images: Correlation of MR Findings with Histologic Features and Expression of Growth FactorsRadiology, 2000
- Effects of cell volume fraction changes on apparent diffusion in human cellsMagnetic Resonance Imaging, 2000
- Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imagingMagnetic Resonance in Medicine, 2000