Modulation of Nitric Oxide Production by Tetracyclines and Chemically Modified Tetracyclines
- 1 November 1998
- journal article
- Published by SAGE Publications in Advances in Dental Research
- Vol. 12 (1), 126-130
- https://doi.org/10.1177/08959374980120010701
Abstract
Chemically modified tetracyclines (CMTs) dose-dependently decreased inducible nitric oxide synthase (iNOS) and, consequently, nitric oxide (NO) formation by the lipopolysaccharide (LPS)-stimulated J774 line. The inhibitory effect was due to a specific reduction in the iNOS protein content in the cells, as attested by Western blot analysis and by the inhibition of iNOS mRNA accumulation. Furthermore, CMTs cause a dose-dependent increase in cell death in the J774 line mediated by the NO-independent apoptotic mechanism.Keywords
This publication has 14 references indexed in Scilit:
- Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.Proceedings of the National Academy of Sciences of the United States of America, 1994
- Modulation of acute inflammation by endogenous nitric oxideEuropean Journal of Pharmacology, 1992
- Features of apoptotic cells measured by flow cytometryCytometry, 1992
- Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthasesFEBS Letters, 1991
- Suppression of human neutrophil functions by tetracyclinesJournal of Periodontal Research, 1991
- Effect of minocycline on prostaglandin formation in gingival fibroblastsJournal of Periodontal Research, 1988
- Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase.Proceedings of the National Academy of Sciences of the United States of America, 1986
- Tetracyclines inhibit tissue collagenase activityJournal of Periodontal Research, 1984
- Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysJournal of Immunological Methods, 1983
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970