Mesenchymal cell remodeling during mouse secondary palate reorientation
Open Access
- 14 June 2010
- journal article
- patterns and-phenotypes
- Published by Wiley in Developmental Dynamics
- Vol. 239 (7), 2110-2117
- https://doi.org/10.1002/dvdy.22339
Abstract
The formation of mammalian secondary palate requires a series of developmental events such as growth, elevation, and fusion. Despite recent advances in the field of palate development, the process of palate elevation remains poorly understood. The current consensus on palate elevation is that the distal end of the vertical palatal shelf corresponds to the medial edge of the elevated horizontal palatal shelf. We provide evidence suggesting that the prospective medial edge of the vertical palate is located toward the interior side (the side adjacent to the tongue), instead of the distal end, of the vertical palatal shelf and that the horizontal palatal axis is generated through palatal outgrowth from the side of the vertical palatal shelf rather than rotating the pre‐existing vertical axis orthogonally. Because palate elevation represents a classic example of embryonic tissue re‐orientation, our findings here may also shed light on the process of tissue re‐orientation in general. Developmental Dynamics 239:2110–2117, 2010.Keywords
This publication has 45 references indexed in Scilit:
- Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate developmentDevelopment, 2008
- Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusionCell and tissue research, 2008
- Zeb1 links epithelial-mesenchymal transition and cellular senescenceDevelopment, 2008
- Molecular control of secondary palate developmentDevelopmental Biology, 2006
- Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusionDevelopmental Biology, 2006
- Fate-mapping of the epithelial seam during palatal fusion rules out epithelial–mesenchymal transformationDevelopmental Biology, 2005
- Overexpression of Smad2 in Tgf-β3-null mutant mice rescues cleft palateDevelopmental Biology, 2005
- Palatal shelf movement during palatogenesis: a fate map of the fetal mouse palate cultured in vitroBrain Structure and Function, 2004
- Snail family members and cell survival in physiological and pathological cleft palatesDevelopmental Biology, 2003
- Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formationDevelopmental Biology, 1990