Regulated functional alternative splicing in Drosophila
Open Access
- 8 September 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 40 (1), 1-10
- https://doi.org/10.1093/nar/gkr648
Abstract
Alternative splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-specific protein isoforms with different functions in development. Alternative splicing is particularly prominent in germ cells, muscle and the central nervous system where it modulates the expression of various proteins including cell-surface molecules and transcription factors. Studies in flies have given us numerous insights into alternative splicing in terms of upstream regulation, the exquisite diversity of their forms and the key differential cellular functions of alternatively spliced gene products. The current inundation of transcriptome sequencing data from Drosophila provides an unprecedented opportunity to gain a comprehensive view of alternative splicing.Keywords
This publication has 79 references indexed in Scilit:
- The developmental transcriptome of Drosophila melanogasterNature, 2010
- Unlocking the secrets of the genomeNature, 2009
- Genome-wide Analysis of Alternative Pre-mRNA Splicing and RNA-Binding Specificities of the Drosophila hnRNP A/B Family MembersMolecular Cell, 2009
- Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintronProceedings of the National Academy of Sciences of the United States of America, 2009
- Alternative isoform regulation in human tissue transcriptomesNature, 2008
- Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogasterInsect Biochemistry and Molecular Biology, 2008
- Dscam diversity is essential for neuronal wiring and self-recognitionNature, 2007
- fruitless Splicing Specifies Male Courtship Behavior in DrosophilaCell, 2005
- Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless GeneCell, 1996
- The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNANature, 1993