Fishing for a Mechanism: Using Zebrafish to Understand Spinal Muscular Atrophy
- 1 August 2007
- journal article
- review article
- Published by SAGE Publications in Journal of Child Neurology
- Vol. 22 (8), 995-1003
- https://doi.org/10.1177/0883073807305671
Abstract
Motoneuron diseases cause paralysis and death due to loss of motoneurons that innervate skeletal muscle. Spinal muscular atrophy is a human motoneuron disease that is genetically linked to the survival motor neuron gene ( SMN). Although SMN was identified more than a decade ago, it remains unclear how decreased levels of the SMN protein cause spinal muscular atrophy. The use of animal models, however, offers a crucial tool in determining the function of SMN in this disease. In this review, we discuss our efforts to develop a zebrafish model of spinal muscular atrophy.Keywords
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