Hepatitis C — Identifying Patients with Progressive Liver Injury
- 1 February 2006
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hepatology
- Vol. 43 (Supplement), S194-S206
- https://doi.org/10.1002/hep.21065
Abstract
Hepatitis C follows a variable course with some patients developing progressive liver fibrosis, cirrhosis and hepatocellular carcinoma, while others have minimal or no significant liver disease after decades of infection. Studies have identified both host and viral factors associated with disease progression. The importance of general factors such as age at infection, gender, immune status and alcohol consumption has long been recognized; however recently, polymorphisms in a wide array of genes have also been shown to be associated with progressive fibrosis. How specific viral proteins may contribute to disease progression has also been studied. This review highlights what is currently known about the factors associated with progressive liver injury in patients with hepatitis C. A greater understanding of the determinants of disease progression will hopefully lead to improved utilization of existing treatments and ultimately may aid in identification of new therapeutic targets. (Hepatology 2006;43;S194–S206.)This publication has 148 references indexed in Scilit:
- Hepatic steatosis in chronic hepatitis B and C: Predictors, distribution and effect on fibrosisJournal of Hepatology, 2005
- Steatosis: Co-factor in other liver diseasesHepatology, 2005
- Fibrosis progression after liver transplantation in patients with recurrent hepatitis CJournal of Hepatology, 2004
- Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analysesHepatology, 2004
- The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patientsJournal of Hepatology, 2004
- Fibrogenic impact of high serum glucose in chro nic hepatitis CJournal of Hepatology, 2003
- Low frequency of cirrhosis in a hepatitis C(genotype 1b) single-source outbreak in germany: A 20-year multicenter studyHepatology, 2000
- Prevalence and Clinical Outcome of Hepatitis C Infection in Children Who Underwent Cardiac Surgery before the Implementation of Blood-Donor ScreeningThe New England Journal of Medicine, 1999
- Long-term follow-up of non-A, non-B (type C) post-transfusion hepatitisJournal of Hepatology, 1992
- Long-term follow-up of posttransfusion and sporadic chronic hepatitis non-A, non-B and frequency of circulating antibodies to hepatitis C virus (HCV)Journal of Hepatology, 1990