Alcohol consumption and frontal lobe shrinkage: study of 1432 non-alcoholic subjects
Open Access
- 1 July 2001
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 71 (1), 104-106
- https://doi.org/10.1136/jnnp.71.1.104
Abstract
OBJECTIVES To evaluate the influences of chronic alcohol consumption on brain volume among social drinkers, as it is well known that alcohol misusers have a high risk of brain shrinkage. METHODS Frontal lobe volumes on MRI were compared with the current alcohol habits of consecutive 1432 non-alcoholic subjects. RESULTS After adjusting for other variables, age was found to be the most powerful promoting factor for the shrinkage with a odds ratio of 2.8 (95% confidence interval (95% CI) 1.23–3.06) for each 10 years of age. Regarding alcohol habit, 667 of the subjects were abstainers, and 157, 362, and 246 of the subjects were light (average 88.2 g ethanol/week), moderate (181.2 g/week), and heavy (418.1 g/week) drinkers, respectively. Moderate alcohol consumption did not increase the incidence of frontal lobe shrinkage (odds ratio 0.98; 95% CI 0.73–1.33), whereas heavy drinkers were at a higher risk compared with abstainers (1.80; 1.32–2.46). The contributory rate of alcohol consumption for frontal lobe shrinkage was 11.3%. CONCLUSION The brain tends to shrink physiologically with age. Heavy alcohol consumption seems to exaggerate this shrinkage in social drinkers. Moderate alcohol consumption does not seem to affect brain volume.Keywords
This publication has 10 references indexed in Scilit:
- Brain shrinkage in alcoholics: a decade on and what have we learned?Progress in Neurobiology, 1999
- Brain impairment in well-nourished chronic alcoholics is related to ethanol intakeAnnals of Neurology, 1997
- Single Photon Emission Computerised Tomography in Chronic AlcoholismThe British Journal of Psychiatry, 1996
- Longitudinal Changes in Magnetic Resonance Imaging Brain Volumes in Abstinent and Relapsed AlcoholicsAlcohol: Clinical and Experimental Research, 1995
- Brain Atrophy and Cognitive Function in Older Abstinent Alcoholic MenAlcohol: Clinical and Experimental Research, 1995
- Significant reversibility of alcoholic brain shrinkage within 3 weeks of abstinenceActa Psychiatrica Scandinavica, 1995
- Brain Proton Magnetic Resonance Spectroscopy Studies in Recently Abstinent Alcoholics*Alcohol: Clinical and Experimental Research, 1995
- Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing.Radiology, 1993
- Brain Gray and White Matter Volume Loss Accelerates with Aging in Chronic Alcoholics: A Quantitative MRI StudyAlcohol: Clinical and Experimental Research, 1992
- Reversible brain shrinkage in abstinent alcoholics, measured by MRINeuroradiology, 1988