Cooperation of signalling pathways in embryonic mammary gland development

1 December 2007

journal article
review article
Published by Springer Science and Business Media LLC in Nature Reviews Genetics

Vol. 8 (12), 963-972
https://doi.org/10.1038/nrg2227

Abstract

Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.

Keywords

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