SpeedSeq: ultra-fast personal genome analysis and interpretation
Open Access
- 10 August 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Methods
- Vol. 12 (10), 966-968
- https://doi.org/10.1038/nmeth.3505
Abstract
SpeedSeq is an open-source software suite offering very fast, accurate and comprehensive analysis of single-nucleotide and structural variants from whole genome sequencing data. SpeedSeq is an open-source genome analysis platform that accomplishes alignment, variant detection and functional annotation of a 50× human genome in 13 h on a low-cost server and alleviates a bioinformatics bottleneck that typically demands weeks of computation with extensive hands-on expert involvement. SpeedSeq offers performance competitive with or superior to current methods for detecting germline and somatic single-nucleotide variants, structural variants, insertions and deletions, and it includes novel functionality for streamlined interpretation.This publication has 20 references indexed in Scilit:
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