Cancer and genomics
- 15 February 2001
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 409 (6822), 850-852
- https://doi.org/10.1038/35057046
Abstract
Identification of the genes that cause oncogenesis is a central aim of cancer research. We searched the proteins predicted from the draft human genome sequence for paralogues of known tumour suppressor genes, but no novel genes were identified. We then assessed whether it was possible to search directly for oncogenic sequence changes in cancer cells by comparing cancer genome sequences against the draft genome. Apparently chimaeric transcripts (from oncogenic fusion genes generated by chromosomal translocations, the ends of which mapped to different genomic locations) were detected to the same degree in both normal and neoplastic tissues, indicating a significant level of false positives. Our experiment underscores the limited amount and variable quality of DNA sequence from cancer cells that is currently available.Keywords
This publication has 5 references indexed in Scilit:
- Initial sequencing and analysis of the human genomeNature, 2001
- Using GeneWise in the Drosophila annotation experimentGenome Research, 2000
- The p53 gene familyOncogene, 1999
- THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIASAnnual Review of Genetics, 1998
- Human CancerPublished by Cambridge University Press (CUP) ,1992