Endocytic pathways and endosomal trafficking: a primer
- 9 February 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Wiener Medizinische Wochenschrift
- Vol. 166 (7-8), 196-204
- https://doi.org/10.1007/s10354-016-0432-7
Abstract
This brief overview of endocytic trafficking is written in honor of Renate Fuchs, who retires this year. In the mid-1980s, Renate pioneered studies on the ion-conducting properties of the recently discovered early and late endosomes and the mechanisms governing endosomal acidification. As described in this review, after uptake through one of many mechanistically distinct endocytic pathways, internalized proteins merge into a common early/sorting endosome. From there they again diverge along distinct sorting pathways, back to the cell surface, on to the trans-Golgi network or across polarized cells. Other transmembrane receptors are packaged into intraluminal vesicles of late endosomes/multivesicular bodies that eventually fuse with and deliver their content to lysosomes for degradation. Endosomal acidification, in part, determines sorting along this pathway. We describe other sorting machinery and mechanisms, as well as the rab proteins and phosphatidylinositol lipids that serve to dynamically define membrane compartments along the endocytic pathway.Keywords
This publication has 97 references indexed in Scilit:
- Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubulesThe EMBO Journal, 2012
- The First Five Seconds in the Life of a Clathrin-Coated PitCell, 2012
- Caveolae and the Regulation of EndocytosisPublished by Springer Science and Business Media LLC ,2012
- Endosome maturationThe EMBO Journal, 2011
- Let's go bananas: revisiting the endocytic BAR codeThe EMBO Journal, 2011
- MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in betweenCurrent Opinion in Cell Biology, 2011
- Rab GEFs and GAPsCurrent Opinion in Cell Biology, 2010
- Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated PitsDevelopmental Cell, 2009
- The multiple faces of caveolaeNature Reviews Molecular Cell Biology, 2007
- The cellular functions of clathrinCellular and Molecular Life Sciences, 2006