Cutaneous Lymphomas With Prominent Granulomatous Reaction
- 1 October 2002
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 26 (10), 1259-1268
- https://doi.org/10.1097/00000478-200210000-00002
Abstract
The presence of a granulomatous reaction in lesions of cutaneous lymphomas has been described in the past in several cases. Especially in mycosis fungoides, a "granulomatous" variant of the disease has been well characterized. We studied the clinicopathologic features of cutaneous lymphomas with prominent granulomatous reaction, including both cutaneous T-cell lymphomas and B-cell lymphomas (primary cutaneous lymphoma 22, secondary cutaneous lymphoma one). Biopsies of 23 patients with histopathologic features of cutaneous T-cell lymphoma or cutaneous B-cell lymphoma with prominent granulomatous reaction were included in this study. A prominent granulomatous reaction was defined as the presence of a granulomatous component exceeding 25% of the dermal infiltrate. There were 14 cases of mycosis fungoides, two of subcutaneous panniculitis-like T-cell lymphoma, four of small/medium pleomorphic T-cell lymphoma, one of follicle center cell lymphoma, one of large B-cell lymphoma, and one of secondary cutaneous peripheral T-cell lymphoma. Altogether, a prominent granulomatous reaction could be observed in 1.8% of all patients with cutaneous lymphoma (primary or secondary) registered in the files of the Department of Dermatology of the University of Graz (Graz, Austria), demonstrating that there is a distinct, albeit small, proportion of cases revealing this peculiar reaction pattern. In seven cases a misdiagnosis of granulomatous dermatitis preceded the correct diagnosis for a period of 1-216 months, suggesting that sequential biopsies and complete phenotypic and molecular genetic analyses should be carried out in cases of "unusual" granulomatous dermatitis.Keywords
This publication has 46 references indexed in Scilit:
- Granulomatous slack skin: report of a case associated with Hodgkin's disease and a review of the literatureBritish Journal of Dermatology, 2006
- Subcutaneous Panniculitis-like T-Cell LymphomaThe American Journal of Surgical Pathology, 1998
- Granulomatous slack skin: A possible precursor of Hodgkin's diseaseJournal of the American Academy of Dermatology, 1995
- Cutaneous large-cell lymphoma histologically resembling sarcoidosisJournal of the American Academy of Dermatology, 1993
- Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: A comparative studyJournal of the American Academy of Dermatology, 1990
- Granulomatous Variants of Cutaneous T-Cell LymphomaThe American Journal of Surgical Pathology, 1988
- Granulomatous reactions in mycosis fungoidesJournal of Surgical Oncology, 1987
- Cutaneous pleomorphic T cell lymphoma: Immunologic, virologic, and T-cell receptor gene rearrangement studies in one European case with initial pseudolymphoma presentationJournal of the American Academy of Dermatology, 1986
- Malignant lymphoma presenting with cutaneous granulomasJournal of the American Academy of Dermatology, 1984
- GRANULOMATOUS MYCOSIS FUNGOIDESBritish Journal of Dermatology, 1970