Maternal lifestyle and environmental risk factors for autism spectrum disorders
Top Cited Papers
Open Access
- 11 February 2014
- journal article
- review article
- Published by Oxford University Press (OUP) in International Journal of Epidemiology
- Vol. 43 (2), 443-464
- https://doi.org/10.1093/ije/dyt282
Abstract
Background: Over the past 10 years, research into environmental risk factors for autism has grown dramatically, bringing evidence that an array of non-genetic factors acting during the prenatal period may influence neurodevelopment. Methods: This paper reviews the evidence on modifiable preconception and/or prenatal factors that have been associated, in some studies, with autism spectrum disorder (ASD), including nutrition, substance use and exposure to environmental agents. This review is restricted to human studies with at least 50 cases of ASD, having a valid comparison group, conducted within the past decade and focusing on maternal lifestyle or environmental chemicals. Results: Higher maternal intake of certain nutrients and supplements has been associated with reduction in ASD risk, with the strongest evidence for periconceptional folic acid supplements. Although many investigations have suggested no impact of maternal smoking and alcohol use on ASD, more rigorous exposure assessment is needed. A number of studies have demonstrated significant increases in ASD risk with estimated exposure to air pollution during the prenatal period, particularly for heavy metals and particulate matter. Little research has assessed other persistent and non-persistent organic pollutants in association with ASD specifically. Conclusions: More work is needed to examine fats, vitamins and other maternal nutrients, as well as endocrine-disrupting chemicals and pesticides, in association with ASD, given sound biological plausibility and evidence regarding other neurodevelopmental deficits. The field can be advanced by large-scale epidemiological studies, attention to critical aetiological windows and how these vary by exposure, and use of biomarkers and other means to understand underlying mechanisms.Keywords
This publication has 132 references indexed in Scilit:
- Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood AutismJama-Journal Of The American Medical Association, 2013
- Brain anomalies in children exposed prenatally to a common organophosphate pesticideProceedings of the National Academy of Sciences of the United States of America, 2012
- Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutationHuman Molecular Genetics, 2012
- Associations between phthalate metabolite urinary concentrations and body size measures in New York City childrenEnvironmental Research, 2012
- Endocrine disruptors and childhood social impairmentNeuroToxicology, 2011
- A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autismAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 2010
- The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changesActa Neuropathologica, 2010
- Analysis of PCB congeners related to cognitive functioning in adolescentsNeuroToxicology, 2009
- The relationship of maternal smoking to psychological problems in the offspringEarly Human Development, 2007
- Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyreneNeuroToxicology, 2007