Damage to the Insula Disrupts Addiction to Cigarette Smoking
Top Cited Papers
- 26 January 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5811), 531-534
- https://doi.org/10.1126/science.1135926
Abstract
A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking.Keywords
This publication has 27 references indexed in Scilit:
- Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspectiveNature Neuroscience, 2005
- Neural systems of reinforcement for drug addiction: from actions to habits to compulsionNature Neuroscience, 2005
- The airway sensory impact of nicotine contributes to the conditioned reinforcing effects of individual puffs from cigarettesPharmacology Biochemistry and Behavior, 2005
- Tobacco abstinence symptom suppression: the role played by the smoking‐related stimuli that are delivered by denicotinized cigarettesAddiction, 2005
- Parsing rewardTrends in Neurosciences, 2003
- Neural responses associated with cue evoked emotional states and heroin in opiate addictsDrug and Alcohol Dependence, 2000
- Taste perception in patients with insular cortex lesions.Behavioral Neuroscience, 1999
- Taste perception in patients with insular cortex lesions.Behavioral Neuroscience, 1999
- Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugsNature, 1996
- Mortality from tobacco in developed countries: indirect estimation from national vital statisticsThe Lancet, 1992