Autoimmune Hemolytic Anemia in Patients with β-Thalassemia Major
- 30 March 2012
- journal article
- case report
- Published by Taylor & Francis Ltd in Pediatric Hematology and Oncology
- Vol. 29 (3), 235-240
- https://doi.org/10.3109/08880018.2012.666782
Abstract
Hemolysis is a common feature in patients with β-thalassemia major. As a result, autoimmune hemolytic anemia complicating β-thalassemia is easily overlooked. Here, the authors described the clinical features and management of 7 patients with β-thalassemia major and autoimmune hemolytic anemia. These patients had fever, cough, and tea-colored urine on admission. The laboratory investigations showed a significant drop in hemoglobin and increased serum bilirubin. Coombs’ tests revealed that anti-immunoglobulin G (IgG) and anti-C3 was positive in 7 and 5 cases, respectively, whereas anti-Rh E alloantibody was positive in 3 cases. All the patients received corticosteroids treatments and blood transfusions. Patients with anti-Rh E alloantibodies also received immunoglobulin treatments. Six of the patients responded well to the management, but 1 patient developed recurrent autoimmune hemolytic anemia that required cyclosporin A treatment. All the patients remained well by following up for more than 6 months.Keywords
This publication has 20 references indexed in Scilit:
- Blood Transfusion and Alloimmunization in Patients with Thalassemia: Multicenter StudyPediatric Hematology and Oncology, 2011
- Alloimmunization and Erythrocyte Autoimmunization in Transfusion-dependent Egyptian Thalassemic PatientsJournal of Pediatric Hematology/Oncology, 2011
- Beta-thalassemiaGenetics in Medicine, 2010
- Dramatic response to rituximab in a child with severe cold autoimmune hemolytic anemia arising after allogeneic hematopoietic SCTBone Marrow Transplantation, 2009
- RBC alloimmunization in blood transfusion‐dependent β‐thalassemia patients in southern IranInternational Journal of Laboratory Hematology, 2006
- β-ThalassemiaThe New England Journal of Medicine, 2005
- Autoantibody formation after alloimmunization: are blood tranfusions a risk factor for autoimmune hemolytic anemia?Transfusion, 2004
- RBC alloimmunization and autoimmunization among transfusion‐dependent Arab thalassemia patientsTransfusion, 2003
- High-Dose Intravenous Immunoglobulin in the Management of Autoimmune Hemolytic Anemia Complicating Thalassemia majorActa Haematologica, 1990
- An Association between Thalassaemia and Autoimmune Haemolytic Anaemia (AIHA)Scandinavian Journal of Haematology, 1981