COVID-19 Associated Invasive Pulmonary Aspergillosis: Diagnostic and Therapeutic Challenges
Open Access
- 22 July 2020
- journal article
- review article
- Published by MDPI AG in Journal of Fungi
- Vol. 6 (3), 115
- https://doi.org/10.3390/jof6030115
Abstract
Aspergillus co-infection in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, leading to acute respiratory distress syndrome, has recently been reported. To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. Importantly, there is currently no agreed case definition of COVID-19 associated invasive pulmonary aspergillosis (CAPA) that could aid in the early detection of this co-infection. Additionally, with the global emergence of triazole resistance, we emphasize the importance of antifungal susceptibility testing in order to ensure appropriate antifungal therapy. Herein is a review of 38 published CAPA cases, which highlights the diagnostic and therapeutic challenges posed by this novel fungal co-infection.Keywords
This publication has 67 references indexed in Scilit:
- What’s new in invasive pulmonary aspergillosis in the critically illIntensive Care Medicine, 2014
- A Clinical Algorithm to Diagnose Invasive Pulmonary Aspergillosis in Critically Ill PatientsAmerican Journal of Respiratory and Critical Care Medicine, 2012
- Diagnosis of Invasive Aspergillosis by a Commercial Real-Time PCR Assay for Aspergillus DNA in Bronchoalveolar Lavage Fluid Samples from High-Risk Patients Compared to a Galactomannan Enzyme ImmunoassayJournal of Clinical Microbiology, 2011
- Diagnosing invasive fungal disease in critically ill patientsCritical Reviews in Microbiology, 2011
- High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal DiseaseClinical Infectious Diseases, 2011
- Galactomannan in Bronchoalveolar Lavage FluidAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary diseaseEuropean Respiratory Journal, 2007
- Multiple-Triazole–Resistant AspergillosisThe New England Journal of Medicine, 2007
- Pulmonary pathology of severe acute respiratory syndrome in TorontoLaboratory Investigation, 2005
- Fatal Aspergillosis in a Patient with SARS Who Was Treated with CorticosteroidsThe New England Journal of Medicine, 2003