Encapsulated photosensitive drugs by biodegradable microcapsules to incapacitate cancer cells
- 27 July 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry
- Vol. 17 (38), 4018-4021
- https://doi.org/10.1039/b708477c
Abstract
A hydrophobic photodynamic therapy drug, hypocrellin B (HB), was accumulated in water-solubilized natural polyelectrolyte microcapsules. The HB can be effectively encapsulated, delivered and subsequently taken up by cancer cells. These intracellular HB-loaded microcapsules show biocompatibility under darkness and high cytotoxicity after irradiation which provides the possibility of controlled delivery and release of drugs.Keywords
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