In vivo functional NMR imaging of resistance artery control
- 1 March 2005
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 288 (3), H1028-H1036
- https://doi.org/10.1152/ajpheart.00780.2004
Abstract
Arterial spin labeling (ASL) in combination with NMR imaging is an in vivo technique that quantifies tissue perfusion in absolute values (ml blood·min−1·g tissue−1) with high temporal (1–10 s) and spatial (0.1–3 mm) resolution. It uses the arterial water spins as endogenous freely diffusible markers of perfusion and, hence, is a totally noninvasive method. The technique has been successfully applied to quantify baseline perfusion in many organs, including the heart, in humans and animals, and results were validated by comparison with gold standards, PET and microspheres, respectively. Because of the high sampling rate of perfusion with ASL and the possibility that measurements could be obtained without harm over indefinite periods of time, the technique has the potential for use in functional investigations of microcirculation regulation and resistance artery control in vivo. We describe examples of the use of ASL to this end. With use of specific technological developments, ASL determination of perfusion can be coupled with simultaneous acquisitions of 1H and 31P NMR spectroscopy data. These protocols offer new possibilities whereby the microcirculatory control of cell oxygenation and high-energy phosphate metabolism can be explored.Keywords
This publication has 71 references indexed in Scilit:
- Letter to the editorJournal of Magnetic Resonance Imaging, 2003
- Methodology of brain perfusion imagingJournal of Magnetic Resonance Imaging, 2001
- Fast High-Resolution Magnetic Resonance Imaging Demonstrates Fractality of Myocardial Perfusion in Microscopic DimensionsCirculation Research, 2001
- In Vivo quantitative mapping of cardiac perfusion in rats using a noninvasive MR spin‐labeling methodJournal of Magnetic Resonance Imaging, 1998
- A general kinetic model for quantitative perfusion imaging with arterial spin labelingMagnetic Resonance in Medicine, 1998
- Multisection cerebral blood flow MR imaging with continuous arterial spin labeling.Radiology, 1998
- Simultaneous determination of muscle perfusion and oxygenation by interleaved NMR plethysmography and deoxymyoglobin spectroscopyNMR in Biomedicine, 1997
- Noninvasive measurement of regional blood flow in manThe American Journal of Surgery, 1990
- Quantification of regional myocardial blood flow in vivo with H215O.Circulation, 1984
- Capillary supply of skeletal muscle fibers in untrained and endurance-trained menAmerican Journal of Physiology-Heart and Circulatory Physiology, 1977