N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual Inhibitor
- 8 December 2014
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 57 (24), 10455-10463
- https://doi.org/10.1021/jm501501a
Abstract
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer revieweKeywords
Funding Information
- Consejo Superior de Investigaciones Científicas (PIE-201280E074)
- European Commission (CM 1207, CM1103)
- Ministerio de Economía y Competitividad (SAF2012-33304)
- Ministry of Education and Science of the Republic of Serbia (172033)
- Fundación Mutua Madrileña (AP103952012)
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