Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Top Cited Papers
- 7 June 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 19 (9), 563-572
- https://doi.org/10.1038/s41577-019-0177-9
Abstract
Remodelling of the immune system with age — immunosenescence — is a substantial contributor to poor health in older adults, with increasing risk of infections, cancer and chronic inflammatory disease contributing to age-related multi-morbidity. What is seldom considered when examining the immune response of an aged individual is that the immune system is profoundly influenced by physical activity. Habitual physical activity levels decline with age, with significant consequences for muscle mass and function. Skeletal muscle is a major immune regulatory organ and generates a range of proteins, termed myokines, which have anti-inflammatory and immunoprotective effects. Several studies indicate that maintaining physical activity has immune benefits in older adults, for example, it reduces the systemic inflammation associated with chronic age-related diseases. Here, we discuss how physical activity can prevent or ameliorate age-related multi-morbidity by boosting immune function, and we consider whether physical activity could improve immunotherapy outcomes in age-related conditions such as cancer.Keywords
This publication has 127 references indexed in Scilit:
- An age-related numerical and functional deficit in CD19+CD24hiCD38hiB cells is associated with an increase in systemic autoimmunityAging Cell, 2013
- The Hallmarks of AgingCell, 2013
- DNA methylation age of human tissues and cell typesGenome Biology, 2013
- Contraction-induced Interleukin-6 Gene Transcription in Skeletal Muscle Is Regulated by c-Jun Terminal Kinase/Activator Protein-1Online Journal of Public Health Informatics, 2012
- Physical Activity, Sedentary Behavior, and Leukocyte Telomere Length in WomenAmerican Journal of Epidemiology, 2012
- Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasisNature, 2012
- Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderlyAging Cell, 2011
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersNature, 2011
- B cells and aging: molecules and mechanismsTrends in Immunology, 2009
- Prolonged exposure of naïve CD8+ T cells to interleukin‐7 or interleukin‐15 stimulates proliferation without differentiation or loss of telomere lengthImmunology, 2006