Asymmetric Construction of Quaternary Carbon Stereocenter by Pd-Catalyzed Intramolecular .ALPHA.-Arylation
- 1 January 2006
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 54 (12), 1743-1744
- https://doi.org/10.1248/cpb.54.1743
Abstract
The catalyst comprised of Pd(OAc)(2) and H(8)-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular alpha-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity.Keywords
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