Luminescence imaging of water during proton‐beam irradiation for range estimation
- 16 October 2015
- journal article
- research article
- Published by Wiley in Medical Physics
- Vol. 42 (11), 6498-6506
- https://doi.org/10.1118/1.4932630
Abstract
Purpose: Proton therapy has the ability to selectively deliver a dose to the target tumor, so the dose distribution should be accurately measured by a precise and efficient method. The authors found that luminescence was emitted from water during proton irradiation and conjectured that this phenomenon could be used for estimating the dose distribution. Methods: To achieve more accurate dose distribution, the authors set water phantoms on a table with a spot scanning proton therapy system and measured the luminescence images of these phantoms with a high-sensitivity, cooled charge coupled device camera during proton-beam irradiation. The authors imaged the phantoms of pure water, fluorescein solution, and an acrylic block. Results: The luminescence images of water phantoms taken during proton-beam irradiation showed clear Bragg peaks, and the measured proton ranges from the images were almost the same as those obtained with an ionization chamber. Furthermore, the image of the pure-water phantom showed almost the same distribution as the tap-water phantom, indicating that the luminescence image was not related to impurities in the water. The luminescence image of the fluorescein solution had ∼3 times higher intensity than water, with the same proton range as that of water. The luminescence image of the acrylic phantom had a 14.5% shorter proton range than that of water; the proton range in the acrylic phantom generally matched the calculated value. The luminescence images of the tap-water phantom during proton irradiation could be obtained in less than 2 s. Conclusions: Luminescence imaging during proton-beam irradiation is promising as an effective method for range estimation in proton therapy.Keywords
This publication has 27 references indexed in Scilit:
- Projection imaging of photon beams using Čerenkov-excited fluorescencePhysics in Medicine & Biology, 2013
- Prompt gamma imaging with a slit camera for real-time range control in proton therapyPhysics in Medicine & Biology, 2012
- Medical physics aspects of particle therapyRadiation Protection Dosimetry, 2009
- Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scansPhysics in Medicine & Biology, 2009
- Efficiency of radioluminescence of water under the action of accelerated electronsInstruments and Experimental Techniques, 2007
- Quantitative comparison of suitability of various beams for range monitoring with induced β+activity in hadron therapyPhysics in Medicine & Biology, 2005
- In-beam PET measurements of β+radioactivity induced by proton beamsPhysics in Medicine & Biology, 2001
- Proton dose monitoring with PET: quantitative studies in LucitePhysics in Medicine & Biology, 1996
- Visualization and Transport of Positron Emission from Proton Activation in vivoScience, 1978
- The Luminescence of Water Excited by Ambient Ionizing RadiationRadiation Research, 1971