Making an Epidermis
- 1 July 2009
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1170 (1), 7-10
- https://doi.org/10.1111/j.1749-6632.2009.04363.x
Abstract
The skin functions as a barrier protecting the body from dehydration and environmental insults. This barrier function is mainly provided by the outermost layer of the skin, the epidermis. The epidermis is maintained by epidermal stem cells which reside in the basal layer and which generate daughter cells that move upward toward the surface of the skin. During this journey, keratinocytes undergo a series of biochemical and morphological changes that result in the formation of the various layers of the epidermis. Eventually, these cells turn into the outermost layer of dead cornified cells that are sloughed into the environment. This review summarizes our current understanding of the mechanisms that control proliferation and differentiation of epidermal stem cells, and thus addresses fundamental processes that control epidermal morphogenesis and function.Keywords
This publication has 22 references indexed in Scilit:
- ΔNp63 knockdown mice: A mouse model for AEC syndromeAmerican Journal of Medical Genetics Part A, 2009
- IKKα Is a p63 Transcriptional Target Involved in the Pathogenesis of Ectodermal DysplasiasJournal of Investigative Dermatology, 2009
- An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell ContributionJournal of Investigative Dermatology, 2008
- More than one way to skin . . .Genes & Development, 2008
- A Functional Enhancer of Keratin14 Is a Direct Transcriptional Target of ΔNp63Journal of Investigative Dermatology, 2007
- p63 induces key target genes required for epidermal morphogenesisProceedings of the National Academy of Sciences of the United States of America, 2007
- p63 regulates proliferation and differentiation of developmentally mature keratinocytesGenes & Development, 2006
- Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationGenes & Development, 2006
- Measurement of the transit time for cells through the epidermis and stratum corneum of the mouse and guinea‐pigCell Proliferation, 1987
- The cell cycle in psoriasis: a reappraisalBritish Journal of Dermatology, 1976