Biodistribution and Magnetic Resonance Imaging of Cross-Linked DTPA Polysaccharides

Abstract

Large polysaccharide complexes, cross-linked with DTPA and chelated with gadolinium have been tested for various potential uses for magnetic resonance imaging (MRI) in rats. Biodistribution and pharmacokinetic data for several of the soluble polymers are presented and compared with Gd-DTPA and GdCl₃. By varying the initial polysaccharide length and ratio of DTPA to glucose units, polymers of molecular weights (mol wt) from 17,000 to several million were formed, giving soluble material, gels, or particles. The larger polymers (mol wt > 100,000) demonstrate prolonged enhancement of the intravascular space, striking renal enhancement, and moderate hepatic uptake. Small particulate material (less than 10 µm) was also successfully used for intravascular enhancement. The material is metabolized and excreted in urine.