Liposome: composition, characterisation, preparation, and recent innovation in clinical applications
- 15 October 2018
- journal article
- review article
- Published by Taylor & Francis Ltd in Journal of Drug Targeting
- Vol. 27 (7), 742-761
- https://doi.org/10.1080/1061186x.2018.1527337
Abstract
In the last decades, pharmaceutical interested researches aimed to develop novel and innovative drug delivery techniques in the medical and pharmaceutical fields. Recently, phospholipid vesicles (Liposomes) are the most known versatile assemblies in the drug delivery systems. The discovery of liposomes arises from self-forming enclosed phospholipid bilayer upon coming in contact with the aqueous solution. Liposomes are uni or multilamellar vesicles consisted of phospholipids produced naturally or synthetically, which are readily non-toxic, biodegradable, and are readily produced on a large scale. Various phospholipids, for instance, soybean, egg yolk, synthetic, and hydrogenated phosphatidylcholine consider the most popular types used in different kinds of formulations. This review summarizes liposomes composition, characterization, methods of preparation, and their applications in different medical fields including cancer therapy, vaccine, ocular delivery, wound healing, and some dermatological applications.Keywords
Funding Information
- National Natural Science Foundation of China (81503007, 21574059)
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