Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors
- 1 April 2006
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 16 (7), 1846-1849
- https://doi.org/10.1016/j.bmcl.2006.01.008
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic AnalysisJournal of Medicinal Chemistry, 2005
- Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent ComplexJournal of Medicinal Chemistry, 2005
- Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I PoisonMolecular Pharmacology, 2004
- The mechanism of topoisomerase I poisoning by a camptothecin analogProceedings of the National Academy of Sciences of the United States of America, 2002
- Effect of Spermine Conjugation on the Cytotoxicity and Cellular Transport of AcridineJournal of Medicinal Chemistry, 2002
- Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cellsCell Chemical Biology, 1999
- Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I PoisonMolecular Pharmacology, 1998
- G2 cell cycle arrest and apoptosis are induced in Burkitt's lymphoma cells by the anticancer agent oracinFEBS Letters, 1997
- Lack of cardiotoxicity of a new antineoplastic agent, a synthetic derivative of indenoisochinoline: comparison with daunorubicin in rabbitsArchives of Toxicology, 1996
- Targeting of cytotoxic agents by polyamines: synthesis of a chlorambucil–spermidine conjugateJournal of the Chemical Society, Chemical Communications, 1992