Primary biliary cirrhosis: new perspectives in diagnosis and treatment
- 1 April 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in Heart
- Vol. 76 (894), 199-206
- https://doi.org/10.1136/pmj.76.894.199
Abstract
Primary biliary cirrhosis (PBC) is a chronic autoimmune disease characterised by cholestatic liver function tests, antimitochondrial antibodies, and abnormal liver histology. Early descriptions of a rare rapidly progressive disease no longer reflect the more indolent progress often seen today. Many patients have significant long term morbidity through symptoms such as fatigue and itch with a minority progressing to liver failure and need for transplantation. The current data on the diagnosis, clinical progression, and treatment of PBC are reviewed.Keywords
This publication has 114 references indexed in Scilit:
- Approaches to a murine model of AMA positive non-suppurative destructive cholangitis (NSDC)Journal of Hepatology, 1998
- Prediction of prognosis of primary biliary cirrhosis in JapanLiver International, 1995
- Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 yearsJournal of Hepatology, 1994
- The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosisHepatology, 1994
- Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitisHepatology, 1992
- A controlled trial of prednisolone treatment in primary biliary cirrhosis: Three-year resultsJournal of Hepatology, 1992
- Serial determination of type III procollagen amino propeptide serum levels in patients with histologically progressive and non-progressive primary biliary cirrhosisJournal of Hepatology, 1992
- Primary Biliary CirrhosisThe New England Journal of Medicine, 1987
- A Prospective Trial of Colchicine for Primary Biliary CirrhosisThe New England Journal of Medicine, 1986
- The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary CirrhosisThe New England Journal of Medicine, 1983