Factors Associated With the Development of Motor Fluctuations and Dyskinesias in Parkinson Disease

Abstract

In Parkinson disease (PD), long-term therapy with levodopa is associated with the development of motor fluctuations and dyskinesias. These motor complications limit the effectiveness of medication treatment and can cause disability and lower quality of life for some patients.^1-3 In the modern era, the incidence of motor fluctuations after 4 to 6 years of levodopa therapy has been reported as 12% to 60% and for dyskinesias 8% to 64%.⁴