Methods of weaning preterm babies <30 weeks gestation off CPAP: a multicentre randomised controlled trial
Open Access
- 18 May 2012
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood: Fetal & Neonatal
- Vol. 97 (4), F236-F240
- https://doi.org/10.1136/adc.2011-300133
Abstract
Background Controversy exists whether different continuous positive airway pressure (CPAP) weaning methods influence time to wean off CPAP, CPAP duration, oxygen duration, Bronchopulmonary Dysplasia (BPD) or length of admission. Aims In a multicentre randomised controlled trial, the authors have primarily compared CPAP weaning methods impact on time to wean off CPAP and CPAP duration and secondarily their effect on oxygen duration, BPD and time of admission. Methods Between April 2006 and October 2009, 177 infants 2: Cycled on and off CPAP with incremental time ‘OFF’. M3: As with m2, cycled on and off CPAP but during ‘OFF’ periods were supported by 2 mm nasal cannula at a flow of 0.5 l/min. Results Based on intention to treat analysis, there was no significant difference in mean GA or birthweight between the groups (27.1±1.4, 26.9±1.6 and 27.3±1.5 (weeks±1SD) and 988±247, 987±249 and 1015±257 (grams±1SD), respectively). Primary outcomes showed M1 produced a significantly shorter time to wean from CPAP (11.3±0.8, 16.8±1.0, 19.4±1.3 (days±1SE) pConclusion Method 1 significantly shortens CPAP weaning time, CPAP duration, oxygen duration, BPD and admission time.This publication has 25 references indexed in Scilit:
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