Mitochondria: Sovereign of inflammation?
- 26 April 2011
- journal article
- review article
- Published by Wiley in European Journal of Immunology
- Vol. 41 (5), 1196-1202
- https://doi.org/10.1002/eji.201141436
Abstract
NLRP3 inflammasome‐dependent inflammatory responses are triggered by a variety of signals of host danger, including infection, tissue damage and metabolic dysregulation. How these diverse activators cause inflammasome activation is poorly understood. Recent data suggest that the mitochondria integrate these distinct signals and relay this information to the NLRP3 inflammasome. Dysfunctional mitochondria generate ROS, which is required for inflammasome activation. On the contrary, the NLRP3 inflammasome is negatively regulated by autophagy, which is a catabolic process that removes damaged or otherwise dysfunctional organelles, including mitochondria. In addition to the processing and secretion of pro‐inflammatory cytokines such as IL‐1β, NLRP3 inflammasome activation also influences cellular metabolic pathways such as glycolysis and lipogenesis. Mapping the connections between mitochondria, metabolism and inflammation is of great interest, as malfunctioning of this network is associated with many chronic inflammatory diseases.Keywords
This publication has 53 references indexed in Scilit:
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeNature Immunology, 2010
- The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin SensitivityCell Metabolism, 2010
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesNature Immunology, 2010
- Influenza virus activates inflammasomes via its intracellular M2 ion channelNature Immunology, 2010
- The InflammasomesCell, 2010
- The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental ColitisImmunity, 2010
- The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNAImmunity, 2009
- Role of BNIP3 and NIX in cell death, autophagy, and mitophagyCell Death & Differentiation, 2009
- MAM: more than just a housekeeperTrends in Cell Biology, 2009
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationNature Immunology, 2008