Clinical Analysis of Intracranial Metastases in Gestational Choriocarcinoma: A Series of 15 Cases
- 1 February 1985
- journal article
- Published by Wiley in Australian and New Zealand Journal of Obstetrics and Gynaecology
- Vol. 25 (1), 16-22
- https://doi.org/10.1111/j.1479-828x.1985.tb00595.x
Abstract
Between 1963 and 1980 we have had experience of 54 patients with gestational choriocarcinoma and 29 are alive, a survival rate of 53.7%. The disease had metastasized to the central nervous system in 15 of these 54 patients, an occurrence rate of cerebral metastases of 27.8%. 13 of these 15 patients have died and 2 are now in a state of remission. Autopsy was performed in 8 cases. The following points are emphasized: cases with the pulmonary disease risk intracranial spread; the serum/cerebrospinal fluid ratio of human chorionic gonadotropin concentrations and computerized tomography are recommended as useful investigations in the diagnosis of CNS disease; decompression surgery in patients with increased intracranial pressure is indispensable; radiotherapy is temporarily effective for brain deposits; powerful systemic chemotherapy using multiple anticancer drugs is suggested to be helpful both in preventing and in treating CNS disease.Keywords
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