An overview of the serpin superfamily
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Open Access
- 1 January 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Genome Biology
- Vol. 7 (5), 216
- https://doi.org/10.1186/gb-2006-7-5-216
Abstract
Serpins are protease inhibitors that use a conformational change to inhibit target enzymes and are important in many proteolytic cascades, including the mammalian coagulation and inflammatory-response pathways.Keywords
This publication has 97 references indexed in Scilit:
- The undecided serpinThe FEBS Journal, 2005
- Molecular mousetraps, α1-antitrypsin deficiency and the serpinopathiesClinical Medicine, 2005
- Association Between Chronic Fatigue Syndrome and the Corticosteroid‐Binding Globulin Gene ALA SER224PolymorphismEndocrine Research, 2004
- Conformational changes in serpins: II. the mechanism of activation of antithrombin by heparinJournal of Molecular Biology, 2000
- Implications for function and therapy of a 2.9 å structure of binary-complexed antithrombinJournal of Molecular Biology, 1998
- Molecular genetics of human antithrombin deficiencyHuman Mutation, 1996
- Hormone binding globulins undergo serpin conformational change in inflammationNature, 1988
- α 2 -Antiplasmin Enschede: Alanine Insertion and Abolition of Plasmin Inhibitory ActivityScience, 1987
- Mutation of Antitrypsin to AntithrombinNew England Journal of Medicine, 1983
- On the active site of proteases. III. Mapping the active site of papain; specific peptide inhibitors of papainBiochemical and Biophysical Research Communications, 1968