A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo
Open Access
- 20 February 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (2), e32094
- https://doi.org/10.1371/journal.pone.0032094
Abstract
Dietary factors regulate immunological function, but the underlying mechanisms remain elusive. Here we show that vitamin B9 is a survival factor for regulatory T (Treg) cells expressing high levels of vitamin B9 receptor (folate receptor 4). In vitamin B9-reduced condition in vitro, Treg cells could be differentiated from naïve T cells but failed to survive. The impaired survival of Treg cells was associated with decreased expression of anti-apoptotic Bcl2 and independent of IL-2. In vivo depletion of dietary vitamin B9 resulted in the reduction of Treg cells in the small intestine, a site for the absorption of dietary vitamin B9. These findings provide a new link between diet and the immune system, which could maintain the immunological homeostasis in the intestine.This publication has 40 references indexed in Scilit:
- Intestinal absorption of water-soluble vitamins in health and diseaseBiochemical Journal, 2011
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- The alliance of sphingosine-1-phosphate and its receptors in immunityNature Reviews Immunology, 2008
- Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epitheliumThe Journal of Experimental Medicine, 2007
- All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulationThe Journal of Experimental Medicine, 2007
- Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidThe Journal of Experimental Medicine, 2007
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanismThe Journal of Experimental Medicine, 2007
- Human reduced folate carrier: translation of basic biology to cancer etiology and therapyCancer and Metastasis Reviews, 2007
- The folate receptor: What does it promise in tissue-targeted therapeutics?Cancer and Metastasis Reviews, 2007
- Folate Production by Bifidobacteria as a Potential Probiotic PropertyApplied and Environmental Microbiology, 2007