Brainstem Serotonergic Deficiency in Sudden Infant Death Syndrome

Abstract
Sudden infant death syndrome (SIDS) is the sudden death of an infant younger than 1 year that remains unexplained after a complete autopsy and death scene investigation.1 Typically, an apparently healthy infant is found dead after a sleep period,2 with death presumably occurring during sleep or one of the many transitions between sleep and waking.3,4 The recognition that prone sleep position increases the risk for SIDS led to national campaigns,5 but despite initial success, the overall SIDS rate has plateaued over the last decade.3,4 SIDS remains the leading cause of postneonatal infant mortality in the United States, with an overall rate of 0.54 per 1000 live births.6,7