Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
- 1 January 2003
- journal article
- letter
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 9 (1), 3-4
- https://doi.org/10.1038/nm0103-3
Abstract
No abstract availableKeywords
This publication has 10 references indexed in Scilit:
- Isolation of Living Neurons from Human Elderly Brains Using the Immunomagnetic Sorting DNA-Linker SystemThe American Journal of Pathology, 2002
- Endosomal Proteolysis of Internalized Insulin at the C-terminal Region of the B Chain by Cathepsin DJournal of Biological Chemistry, 2002
- Alzheimer's Disease: Genes, Proteins, and TherapyPhysiological Reviews, 2001
- BACE1 is the major β-secretase for generation of Aβ peptides by neuronsNature Neuroscience, 2001
- Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive DeclineJAMA, 2000
- Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activityNature, 1999
- Purification and cloning of amyloid precursor protein β-secretase from human brainNature, 1999
- β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACEScience, 1999
- Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein productionNature, 1992
- A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloidNature Genetics, 1992