Lead- and drug-like compounds: the rule-of-five revolution
Top Cited Papers
- 31 December 2004
- journal article
- review article
- Published by Elsevier BV in Drug Discovery Today: Technologies
- Vol. 1 (4), 337-341
- https://doi.org/10.1016/j.ddtec.2004.11.007
Abstract
No abstract availableKeywords
This publication has 39 references indexed in Scilit:
- Defining Privileged Reagents Using Subsimilarity ComparisonJournal of Chemical Information and Computer Sciences, 2004
- Log(BB), PS products and in silico models of drug brain penetrationDrug Discovery Today, 2004
- Blood-Brain Barrier Permeation Models: Discriminating between Potential CNS and Non-CNS Drugs Including P-Glycoprotein SubstratesJournal of Chemical Information and Computer Sciences, 2004
- A ‘Rule of Three’ for fragment-based lead discovery?Drug Discovery Today, 2003
- A structure–Permeability study of small drug-like moleculesBioorganic & Medicinal Chemistry Letters, 2003
- Strategies for NMR Screening and Library DesignMethods and Principles in Medicinal Chemistry, 2002
- Molecular Properties That Influence the Oral Bioavailability of Drug CandidatesJournal of Medicinal Chemistry, 2002
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 1997
- The Properties of Known Drugs. 1. Molecular FrameworksJournal of Medicinal Chemistry, 1996
- Functional group contributions to drug-receptor interactionsJournal of Medicinal Chemistry, 1984