Magnetic resonance imaging for evaluation of Crohnʼs disease
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- 1 August 2011
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Inflammatory Bowel Diseases
- Vol. 17 (8), 1759-1768
- https://doi.org/10.1002/ibd.21551
Abstract
The use of magnetic resonance imaging (MRI) for assessment of Crohn's disease (CD) is expanding. The aim of this study is to define and provide an external validation of the MRI predictors of active CD, severe CD, and a quantitative Magnetic Resonance Index of Activity (MaRIA). In all, 48 patients with clinically active (n = 29) or inactive (n = 19) CD underwent ileocolonoscopy (reference standard) and MRI. T2-weighted and pre- and postcontrast-enhanced T1-weighted sequences were acquired. Endoscopic activity was evaluated by the Crohn's Disease Endoscopic Index of Severity (CDEIS), and also classified as absent, mild (inflammation without ulcers), or severe (presence of ulceration). In complete agreement with a previous derivation study, independent predictors of disease severity using CDEIS as a reference were wall thickness, relative contrast enhancement (RCE), presence of edema, and ulcers on MRI. Estimation of activity in each segment using this regression model, or another with simplified coefficients (MaRIA(S) = 1.5*wall thickness + 0.02*RCE + 5*edema + 10*ulceration) correlated with CDEIS (r = 0.798, P< 0.001; r = 0.80 P < 0.001, respectively). In the validation cohort both indexes had a high and equal accuracy for diagnosis of active disease: receiver operator characteristic (ROC) area 0.93, sensitivity 0.87, specificity 0.87 using a cutoff point ≥ 7, and for diagnosis of severe disease: ROC area 0.96, sensitivity 0.92, specificity 0.92 using a cutoff point ≥ 11. The total of segment values (MaRIA(T)) correlated with global CDEIS (r = 0.83, P< 0.001). The MRI variables that should be evaluated in clinical practice to diagnose active CD and severe CD are validated, as well as the quantitative index of activity for use in research studies.This publication has 20 references indexed in Scilit:
- Prospective Comparison of State-of-the-Art MR Enterography and CT Enterography in Small-Bowel Crohn's DiseaseAmerican Journal of Roentgenology, 2009
- Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's diseaseGut, 2009
- Comparison of magnetic resonance imaging colonography with conventional colonoscopy for the assessment of intestinal inflammation in patients with inflammatory bowel disease: a feasibility studyGut, 2005
- Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activityGut, 2005
- External validation is necessary in prediction research:Journal of Clinical Epidemiology, 2003
- Evidence base of clinical diagnosis: Evaluation of diagnostic proceduresBMJ, 2002
- Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data setsStatistics in Medicine, 2000
- Bowel disease: Prospective comparison of CT and 1.5‐T pre‐ and postcontrast MR imaging with T1‐weighted fat‐suppressed and breath‐hold FLASH sequencesJournal of Magnetic Resonance Imaging, 1991
- A note on a general definition of the coefficient of determinationBiometrika, 1991
- A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITYThe Lancet, 1980