Air Pollution and Markers of Inflammation and Coagulation in Patients with Coronary Heart Disease
- 15 February 2006
- journal article
- research article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 173 (4), 432-441
- https://doi.org/10.1164/rccm.200507-1123oc
Abstract
Rationale: Ambient air pollution has been shown to be associated with cardiovascular morbidity and mortality. Objectives: A prospective panel study was conducted to study the early physiologic reactions characterized by blood biomarkers of inflammation, endothelial dysfunction, and coagulation in response to daily changes in air pollution in Erfurt, Germany. Methods: Blood parameters were repeatedly measured in 57 male patients with coronary heart disease during the winter of 2000/2001. Fixed-effects linear and logistic regression models were applied, adjusting for trend, weekday, and meteorologic parameters. Measurements: Hourly data on ultrafine particles (UFPs; number concentration of particles from 0.01 to 0.1 μm), mass concentration of particles less than 10 (PM10) and 2.5 μm in diameter, elemental and organic carbon, gaseous pollutants, and meteorologic data were collected at central monitoring sites. Main Results: Increased levels of C-reactive protein above the 90th percentile were observed for an increase in air pollution concentrations of one interquartile range. The effect was strongest for accumulation mode particles, with a delay of 2 d (odds ratio [OR], 3.2; confidence interval [CI], 1.7, 6.0). Results were consistent for UFPs and PM10, which also showed a 2-d delayed response (OR, 2.3; CI, 1.3, 3.8; and OR, 2.2; CI, 1.2, 3.8, respectively). However, not all of the blood markers of endothelial dysfunction and coagulation increased consistently in association with air pollutants. Conclusion: These results suggest that inflammation as well as parts of the coagulation pathway may contribute to the association between particulate air pollution and coronary events.This publication has 47 references indexed in Scilit:
- Relationship between indoor and outdoor levels of fine particle mass, particle number concentrations and black smoke under different ventilation conditionsJournal of Exposure Science & Environmental Epidemiology, 2004
- Foundation and sites of action of antithrombotic agentsBest Practice & Research Clinical Haematology, 2004
- Ultrafine Particles Exert Prothrombotic but Not Inflammatory Effects on the Hepatic Microcirculation in Healthy Mice In VivoCirculation, 2004
- Platelet Interactions in ThrombosisIUBMB Life, 2004
- The Role of Soluble Components in Ambient Fine Particles-Induced Changes in Human Lungs and BloodInhalation Toxicology, 2003
- Morphological aspects of particle uptake by lung phagocytesMicroscopy Research and Technique, 2002
- Association between Ambient Carbon Monoxide Levels and Hospitalizations for Congestive Heart Failure in the Elderly in 10 Canadian CitiesEpidemiology, 1997
- Performance of a mobile aerosol spectrometer for an in situ characterization of environmental aerosols in Frankfurt cityAtmospheric Environment. Part A. General Topics, 1992
- Particulate air pollution and daily mortality in detroitEnvironmental Research, 1991
- Relationship between Platelet Secretion and Prothrombin Cleavage in Native Whole BloodJCI Insight, 1981