Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions
Open Access
- 25 September 2012
- journal article
- review article
- Published by Hindawi Limited in Journal of Biomedicine and Biotechnology
- Vol. 2012, 1-16
- https://doi.org/10.1155/2012/379024
Abstract
Inflammation and insulin resistance are common in several chronic diseases, such as obesity, type 2diabetes mellitus, metabolic syndrome, cancer, and cardiovascular diseases. Various studies show a relationship between these two factors, although the mechanisms involved are not completely understood yet. Here, we discuss the molecular basis of insulin resistance and inflammation and the molecular aspects on inflammatory pathways interfering in insulin action. Moreover, we explore interventions based on molecular targets for preventing or treating correlated disorders, advances for a better characterization, and understanding of the mechanisms and mediators involved in the different inflammatory and insulin resistance conditions. Finally, we address biotechnological studies for the development of new potential therapies and interventions.This publication has 179 references indexed in Scilit:
- Inflammation and Lipid Signaling in the Etiology of Insulin ResistanceCell Metabolism, 2012
- A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13Cell, 2012
- Oxidative stress, insulin signaling, and diabetesFree Radical Biology & Medicine, 2010
- Oxidative stress and the etiology of insulin resistance and type 2 diabetesFree Radical Biology & Medicine, 2010
- GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing EffectsCell, 2010
- Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetesDiabetologia, 2010
- How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic IsletsImmunity, 2009
- Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritisExperimental and Molecular Pathology, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Effects of Etanercept in Patients With the Metabolic SyndromeArchives of Internal Medicine, 2006