Studies on pregnancy-associated globulin.

Abstract

Using a radial immunodiffusion technique the serum levels of pregnancy-associated globulin (PAG) have been measured in eighteen females before and during administration of combined oestrogen/progestogen oral contraceptives, in twenty-eight females before and after the oestrogen or progestogen component of oral contraceptives and in ten males before and during stilboestrol therapy for prostatic carcinoma. Significant increases in PAG levels were observed during administration of (1) combined oestrogen/progestogen oral contraceptives, (2) the oestrogen component of the oral contraceptive and (3) stilboestrol. No change was observed after administration of the progestogen component.