Holothurian Fucosylated Chondroitin Sulfate
Open Access
- 9 January 2014
- journal article
- review article
- Published by MDPI AG in Marine Drugs
- Vol. 12 (1), 232-254
- https://doi.org/10.3390/md12010232
Abstract
Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates. However, FucCS has also sulfated fucosyl branching units 3-O-linked to the acid residues. The sulfation patterns of these branches vary accordingly with holothurian species and account for different biological actions and responses. FucCSs may exhibit anticoagulant, antithrombotic, anti-inflammatory, anticancer, antiviral, and pro-angiogenic activities, besides its beneficial effects in hemodialysis, cellular growth modulation, fibrosis and hyperglycemia. Through an historical overview, this document covers most of the science regarding the holothurian FucCS. Both structural and medical properties of this unique GAG, investigated during the last 25 years, are systematically discussed herein.Keywords
This publication has 66 references indexed in Scilit:
- Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis via Targeting of Nuclear Factor-κB/Tissue Factor/Factor Xa Pathway in Melanoma B16F10 CellsPLOS ONE, 2013
- Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea CucumbersMarine Drugs, 2013
- Preparation and Characterization of O-Acylated Fucosylated Chondroitin Sulfate from Sea CucumberMarine Drugs, 2012
- Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and ChallengesMarine Drugs, 2012
- Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbersCarbohydrate Polymers, 2011
- Fucosylated chondroitin sulfate attenuates renal fibrosis in animals submitted to unilateral ureteral obstruction: a P-selectin-mediated event?American Journal of Physiology-Renal Physiology, 2010
- Physicochemical characteristics and anticoagulant activities of low molecular weight fractions by free-radical depolymerization of a fucosylated chondroitin sulphate from sea cucumber Thelenata ananasFood Chemistry, 2010
- Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exositeBlood, 2009
- Review: An overview about the structure–function relationship of marine sulfated homopolysaccharides with regular chemical structuresPeptide Science, 2009
- Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanismBlood, 2006