North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research
- 19 March 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 33 (3), 665-672
- https://doi.org/10.1093/schbul/sbl075
Abstract
This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.Keywords
This publication has 20 references indexed in Scilit:
- Prevention of Missing Data in Clinical Research StudiesBiological Psychiatry, 2006
- Psychometric Properties of the Life Events ChecklistAssessment, 2004
- Identification of separable cognitive factors in schizophreniaSchizophrenia Research, 2004
- The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis: I. Study rationale and designSchizophrenia Research, 2003
- The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis: II. Baseline characteristics of the “prodromal” sampleSchizophrenia Research, 2003
- Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to ReliabilitySchizophrenia Bulletin, 2003
- Early and Late Neurodevelopmental Influences in the Prodrome to Schizophrenia: Contributions of Genes, Environment, and Their InteractionsSchizophrenia Bulletin, 2003
- Prospective Diagnosis of the Initial Prodrome for Schizophrenia Based on the Structured Interview for Prodromal Syndromes: Preliminary Evidence of Interrater Reliability and Predictive ValidityAmerican Journal of Psychiatry, 2002
- Strauss (1969) revisited: a psychosis continuum in the general population?Schizophrenia Research, 2000
- Assessing traumatic event exposure: General issues and preliminary findings for the Stressful Life Events Screening QuestionnaireJournal of Traumatic Stress, 1998